Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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pentobarbital will decrease the extent or effect of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.
pentobarbital will lower the level or effect of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will decrease the level or effect of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lessen the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to the lessen in fentanyl plasma concentrations, insufficient efficacy or, possibly, enhancement of the withdrawal syndrome in the affected person who's got created Bodily dependence to fentanyl.
The speed of IV injection mustn't exceed 50 mg/min for pentobarbital sodium. There is absolutely no regular intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can be relied on to provide equivalent effects in numerous individuals. The possibility of overdose and respiratory melancholy is remote if the drug is injected slowly but surely in fractional doses. A usually used First dose for your 70 kg Grownup is one hundred mg. Proportional reduction in dosage need to be designed for pediatric or debilitated sufferers. A minimum of a person minute is important to ascertain the total effect of intravenous pentobarbital. If vital, extra compact increments in the drug may very well be offered nearly a total of from 200 to 500 mg for ordinary adults.
pentobarbital will decrease the level or effect of armodafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.
Monoamine oxidase inhibitors (MAOI): MAOI lengthen the effects of barbiturates almost certainly simply because metabolism on the barbiturate is inhibited.
pentobarbital will reduce the level or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Strong CYP3A4 inducers may well reduce suvorexant efficacy; if amplified suvorexant dose necessary, never exceed 20 mg/day
pentobarbital will minimize the extent or effect of vincristine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.
pentobarbital click here will reduce the level or effect of estrogens conjugated synthetic by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or effect of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will increase the level or effect of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with strong CYP3A4 inducers decreased ivosidenib plasma concentrations.
pentobarbital will lessen the extent or effect of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.
Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (name Formerly used: bishydroxycoumarin) and causes a minimize in anticoagulant action as calculated because of the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in amplified metabolism and reduced anticoagulant reaction of oral anticoagulants (e.